ما هو علاج الخط الأول لالتهاب القولون المجهري؟

References

DOI: 10.1177/2050640620951905

• We recommend using oral budesonide to induce remission in patients with CC.
• We recommend using oral budesonide to induce remission in patients with LC.
• After six to eight weeks of treatment, pooled analysis revealed 81% (62/77) of patients treated with budesonide 9 mg/d achieved a clinical response compared to 36% (30/84) of patients treated with placebo (relative risk (RR) 2.98, 95% CI: 1.14–7.75; random-effects).
• We suggest to consider withdrawal of any drugs with a suspected chronological relationship between drug introduction and onset of diarrhoea.
• Given the documented effect in patients with chronic diarrhoea, the expert's opinion favours the use of this drug in mild disease.
• Statement 3.4: In the absence of a formally validated metric of disease activity, disease activity and clinical remission in MC should be assessed by the Hjortswang criteria (clinical remission: mean of <3 stools per day and a mean <1 water stool per day during a one-week registration).
• Therefore, it was proposed that remission in CC should be defined as a mean of <3 stools per day and a mean <1 watery stool per day during a one-week registration.