سرطان خلايا ميركل الموضعي مع ورم أولي غير قابل للجراحة: ماذا تفعل عندما لا تكون الجراحة خياراً متاحاً

References

• In some patients, surgical therapy is not feasible due to the extent of disease (technically inoperable) or the presence of significant (co)morbidity.
• When WLE is not feasible, definitive RT of the primary tumour is an alternative approach.
• Since MCC is radiosensitive, RT as a single modality is an alternative to surgery in this group.
• Independently, the European Consensus-based interdisciplinary guideline and NCCN guidelines propose doses of 60-66 Gy for definitive treatment of patients with grossly positive primary tumour resection margins and/or clinically evident lymphadenopathy.
• Patients with N0 disease eligible for immunotherapy should be preferably considered for anti-PD-1 therapy and reassessed for response and suitability for surgery by an MDT.

DOI: 10.1016/j.esmoop.2024.102977