الحزاز البسيط المزمن عندما لا تتمكن العوامل الجهازية من السيطرة على الحكة والحك

References

DOI: 10.1007/s40257-025-00979-z

• Cryosurgery, which involves freezing and destroying abnormal skin cells, helps alleviate pruritus by flattening the thickened plaques characteristic of LSC and disrupting the itch-scratch cycle by reducing cutaneous nerve endings.
• A 2022 meta-analysis of clinical studies found that adding liquid nitrogen cryotherapy to conventional topical treatment significantly improved LSC outcomes without increasing adverse effects.
• Serial electrobrasion was successfully used to treat a 67-year-old male with refractory lichenified plaques on his lower extremities.
• Ablative fractional CO2 laser (AFXL) is emerging as a therapy to reduce thickness and induce regeneration in lichenified skin.
• Narrowband UVB (NB-UVB) phototherapy significantly reduces pruritus with minimal side effects.
• High-frequency focused ultrasound is a novel device therapy mentioned in recent literature for vulvar LSC.
• Botulinum toxin type A (BoNTA) has also shown promise in the treatment of recalcitrant localized pruritus in LSC.