علاج متلازمة لينوكس-غاستو عندما يبقى ضبط النوبات دون المستوى الأمثل

References

DOI: 10.1002/epi4.13075

If seizure control remains suboptimal, subsequent adjunctive ASM treatment options include (alphabetically) cannabidiol, clobazam, felbamate, fenfluramine, and topiramate, although evidence for these is more limited.

When considering adding an adjunctive therapy, every attempt should be made to discontinue one of the two previous ASMs once the new ASM has been introduced, since there is no evidence for the effectiveness of more than two ASMs in combination, and the use of multiple ASMs unnecessarily raises the risk of side effects and/or drug–drug interactions.