علاج داء هيستيوسيت خلايا لانغرهانس المشمول فيه الدماغ لدى البالغين

References

DOI: 10.1182/blood.2021014343

For LCH involving the brain parenchyma, first-line treatment with chemotherapy with cladribine or cytarabine is recommended.

For patients with CNS disease, cladribine, higher doses of cytarabine, IV methotrexate-based regimens, or kinase inhibitors are preferred.

For initially FDG PET avid LCH, it is recommended to repeat an FDG PET-based imaging study for assessment of disease response after 2-3 mo of initiation of therapy, with subsequent imaging frequency tailored individually based on the specific clinical scenario.