التهاب مفصل الركبة التنكسي حالة مفصلية شائعة تدعم الإرشادات السريرية باستمرار استخدام العلاج الموضعي المُطبَّق مباشرةً على الركبة المصابة ضمن إدارة الخط العلاجي الأول. وقد قيّمت العديد من هيئات الإرشادات الكبرى هذا النهج وأصدرت توصيات بشأنه.
Topical NSAIDs were uniformly strongly recommended for knee OA by all guidelines and were strongly and conditionally recommended for hand OA by EULAR and ACR/AF, respectively, with the strength of recommendation influenced by practicality of using topical agents on finger joints.
In contrast, topical capsaicin was conditionally or weakly recommended for knee OA by ACR/AF and VA/DOD, but conditionally recommended against by OARSI.
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