علاج الكيراتواكانثوما عندما لا تكون الجراحة الخيار الأول

DOI: 10.3390/ijms262010040

• Radiotherapy (RT) and cryotherapy are physical therapies for treating KAs.
• Although cryotherapy has not been widely studied as a therapeutic option, its effectiveness has been reported in about 87% of KAs.
• Photodynamic therapy (PDT) also belongs to the group of physical therapies.
• The argon lasers have also been used for KAs.
• Topical 5-fluorouracil (5-FU) and imiquimod represent two valuable alternatives for KAs.
• Indeed, the use of topical 5-FU led to a complete resolution of the lesion within six weeks in a retrospective analysis.
• 5-FU can also be used for intralesional applications.
• An average of three injections in three weeks has been reported as effective.
• However, imiquimod should be applied for 9–11 weeks, three to four times a week, to obtain a complete remission.
• Intralesional administration of MTX is considered another alternative to surgery.
• Furthermore, Annest et al. reported in a review that intralesional MTX achieved resolution in 92% of patients, requiring an average of two injections 18 days apart.