الذبحة الصدرية المستمرة بعد العلاج المضاد للذبحة من الخط الثاني في مرض القلب الإقفاري

References

DOI: 10.1093/eurheartj/suaa060

• The guidelines suggest it if the symptoms are not well-controlled with BB, calcium channel blockers, or nitrates or if hypotension and bradycardia limit the use of these drugs (Class IIa indication of European and American guidelines).
• The study, carried out with 12-week follow-up, involved 823 adults with chronic symptomatic angina, who were randomized to receive placebo or two different dosages of ranolazine (750 mg or 1000 mg 2/day).
• Several studies have confirmed the effectiveness of ranolazine in reducing angina symptoms and angina-free exercise time.
• In the treated group a reduction in the frequency of angina attacks and a reduction in the use of sublingual nitrates was highlighted.