أعراض القولون العصبي المستمرة بعد نظام FODMAP المنخفض — الخطوة التالية الموصى بها

References

Tricyclic antidepressants used as gut-brain neuromodulators are an effective second-line drug for global symptoms and abdominal pain in IBS. They can be initiated in primary or secondary care, but careful explanation as to the rationale for their use is required, and patients should be counselled about their side-effect profile. They should be commenced at a low dose and titrated slowly (recommendation: strong, quality of evidence: moderate).

TCAs should be taken in the evening, before bedtime, due to their sedating effects, and may also improve sleep patterns.

Selective serotonin reuptake inhibitors used as gut-brain neuromodulators may be an effective second-line drug for global symptoms in IBS. As with tricyclic antidepressants, they can be initiated in primary or secondary care, but careful explanation as to the rationale for their use is required, and patients should be counselled about their side-effect profile (recommendation: weak, quality of evidence: low).

DOI: 10.1136/gutjnl-2021-324598