ورم الأنسولين المتقدم عندما تفشل نظائر السوماتوستاتين في السيطرة على نقص سكر الدم

References

• The management of functioning Pan-NET syndromes in patients with advanced disease, that is, unresectable or metastatic, requires a multimodal approach consisting of supportive, medical, interventional and surgical treatment.
• Consequently, both PRRT with 177Lu-DOTATATE and everolimus can be considered in advanced insulinoma cases with hypoglycaemia refractory to SSA, especially in those cases with concurrent progressive disease.
• In a retrospective, multicentre series 11 out of 12 patients demonstrated swift disappearance of hypoglycaemic symptoms with a median symptom-free period of 6.5 months, although tolerance was limited.