التشنجات الرضيعية مع التصلب الدرني: ماذا تفعل عندما لم يُجدِ الفيغاباترين نفعاً

References

DOI: 10.3978/j.issn.2224-4336.2015.09.01

• Vigabatrin is the preferred first-line therapy for patients with infantile spasms and tuberous sclerosis, with some studies showing efficacy of greater than 90% in patients with tuberous sclerosis.
• For example, patients with tuberous sclerosis are more likely to respond to treatment with vigabatrin, whereas patients without an identified etiology may respond better to hormonal therapy.
• It is recommended to try two first-line therapies before moving on to other options, as there is less data to support the second-line treatments.
• Studies have reported patients that respond to ACTH after failing corticosteroids and vice-versa.
• The goals of therapy should include a complete cessation of the clinical events and resolution of hypsarrhythmia or modified hypsarrhythmia on video EEG.
• Response is typically seen within 14 days or sooner.