علاج التشنجات الرضيعية في الحالات المجهولة السبب مع التطور الطبيعي قبل البداية

References

DOI: 10.3978/j.issn.2224-4336.2015.09.01

• For simplicity, this review will use the dichotomous definition.
• Defines symptomatic infantile spasms as those patients with either abnormal development and/or a clear etiology for the infantile spasms and cryptogenic spasms as those occurring in the context of normal development without a clear etiology.
• For example, patients with tuberous sclerosis are more likely to respond to treatment with vigabatrin, whereas patients without an identified etiology may respond better to hormonal therapy.
• ACTH is probably the most universally accepted first-line treatment of infantile spasms, stemming from the class 1 randomized controlled trials performed from 1983–1999 that show its efficacy.
• The goals of therapy should include a complete cessation of the clinical events and resolution of hypsarrhythmia or modified hypsarrhythmia on video EEG.
• Response is typically seen within 14 days or sooner.