اعتلال كلية IgA في الأطفال: ماذا نفعل عندما لا يحقق علاج جرعات الكورتيكوستيرويد أهداف البيلة البروتينية

In this guideline, we define children as those aged <18 years, but it is acknowledged that postpubertal children may in some respects have a similar course and response to treatment as adults with IgAN.

Another potential approach in these children is the use of immunosuppressants (e.g., calcineurin inhibitors, cyclophosphamide, mizoribine where available, mycophenolate mofetil, or rituximab) in addition to glucocorticoids.

As in adults, children with rapidly progressive IgAN have a poor outcome, and despite limited evidence, this subgroup should be offered treatment with systemic glucocorticoids (usually as methylprednisolone pulses) and cyclophosphamide.