علاج سرطان الحنجرة السفلية الحرشفي الخلوي في المرحلة المبكرة (cT1–T2، N0، M0) مع إمكانية الحفاظ على الحنجرة

References

• Early stage disease is defined as either T1–T2 N0 (stage I and II) oral cavity, laryngeal, hypopharyngeal and p16-negative oropharyngeal cancer or T1–T2 N0 p16-positive oropharyngeal cancer according to the UICC TNM 8th edition.
• Larynx-preserving surgery feasible
• RT (T and N) [IV, A]
• Conservation larynx surgery (T and N) followed by RT or CRT if indicated [IV, A]
• Early-stage disease can be treated by RT alone without any use of concomitant or induction ChT [IV, A].
• For stage I disease, a standard fractionation regimen with a primary tumour dose ranging from 66 to 70 Gy depending on the tumour volume and location is recommended [IV, A].
• Early disease should be treated as much as possible with a single-modality treatment (surgery or RT) [IV, A].