علاج داء هنتنغتون عندما يسبب الرقاص ضائقة أو انزعاجًا

References

1. Chorea is characterized by abnormal, involuntary, spontaneous, uncontrollable, irregular, intermittent, non-rhythmic and aimless movements affecting the trunk, the face, and the limbs.
2. Drug treatment should be considered if chorea causes the patient distress or discomfort.
3. Tetrabenazine is one of the first-line treatments for this symptom (Grade A) unless the patient suffers from not well-managed depression or suicidal thoughts.
4. Second generation neuroleptics (Grade B) are first-line treatments for this symptom in particular when the patients have associated personality and/or behavioral or psychotic disorders.
5. Monotherapy to treat chorea is preferred because combination therapy increases the risk of adverse effects and may complicate the management of non-motor symptoms.
6. Deutetrabenazine may indeed be proposed as an alternative to tetrabenazine for the treatment of chorea in countries where the marketing authorization is already obtained, like in the USA.