علاج الرنح المخيخي النخاعي الوراثي في التشنج العضلي المعمّم

References

• Spasticity is the presence of increased muscle tone or hypertonia, caused by a lesion of the upper motor neurones which can cause muscle stiffness, spasms and pain.
• Spasticity has also been described more rarely in a range of other autosomal recessive ataxias, spastic paraplegias and autosomal dominant ataxias including SCAs 1–3, 6–8, 10–12, 17, 23, 28, 30, and 35.
• If these are not successful or not tolerated, greater CNS concentrations of baclofen can be achieved with reduced peripheral exposure to side effects by the use of an intrathecal baclofen infusion, although this requires careful patient selection, planning and an expert centre to undertake the procedure and follow-up.