علاج داء ترسب الأصبغة الدموية الوراثي في داء ترسب الأصبغة الصغاري أو داء ترسب الأصبغة الشديد مع فرط تحميل الحديد القلبي المهدد للحياة

References

DOI: 10.1016/j.jhep.2022.03.033

• In juvenile haemochromatosis, where chelation is typically begun in life-threatening cardiac iron overload, combination chelation therapy with oral DFP and intravenous DFO has been described in several case reports.
• In the presence of severe clinical manifestations, a combined or alternative chelating therapy is generally required in the unloading phase.
• In patients with advanced disease who poorly tolerate classical phlebotomies (e.g. because of low baseline haemoglobin or hemodynamically unstable because of cardiac impairment), personalised (mini)-phlebotomies plus subcutaneous infusion of deferoxamine (DFO) could be considered.