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References

DOI: 10.1016/j.jhep.2022.03.033

• Patients with haemochromatosis and evidence of iron overload should undergo iron depletion therapy.
• The first-line treatment for iron depletion is therapeutic phlebotomy.
• Erythrocytapheresis is an alternative to therapeutic phlebotomy and has been shown to be cost effective in the induction phase, because fewer interventions are required, and it can be an option if available.
• The target for iron depletion during induction is a serum ferritin of 50 µg/L, but not lower to avoid iron deficiency.
• In the maintenance phase, serum ferritin can be maintained with some flexibility in the range of 50–100 µg/L.