عندما تفشل الوقاية طويلة الأمد من الخط الأول في تحقيق السيطرة الكاملة على نوبات الوذمة الوعائية الوراثية

References

DOI: 10.1111/all.15214

• Long-term prophylaxis should be individualized and considered in all HAE-1/2 patients taking into consideration the disease activity, patient's quality of life, availability of health care resources, and failure to achieve adequate control by appropriate on-demand therapy.
• We recommend the use of androgens only as second-line long-term prophylaxis.
• The minimal effective dose should be used.
• Alternative options for LTP, in the absence of all three first-line LTP treatments, include the off-label use of intravenous recombinant C1-INH.