ما هو علاج الخط الأول لسرطان الغدد الليمفاوية من الخلايا التائية الكبدية الطحالية؟

References

DOI: 10.1182/bloodadvances.2025015857

• The most accepted therapy paradigm is to initiate intensive, multiagent chemotherapy induction regimens.
• Commonly used induction regimens include those containing platinum agents (such as ICE in case 3) and cytarabine (such as IVAC [ifosfamide, etoposide, and cytarabine]), which may induce superior responses compared with anthracycline-containing regimens (CHOP [cyclophosphamide, doxorubicin, vincristine, and prednisone] or CHOP-like).
• Antimetabolite therapy (eg, pentostatin and pralatrexate) either as monotherapy or in combination with other agents may be effective.
• Of note, splenectomy is not necessary nor recommended upfront. It should be considered only in specific clinical scenarios or to support the start of treatment (eg, pain control, quality of life, or thrombocytopenia management).
• The goal of induction chemotherapy is to produce a CR or near-CR before proceeding with consolidative approaches, such as HSCT.