علاج الهيموفيليا أ الشديدة بدون مثبطات في البيئات محدودة الموارد

References

DOI: 10.1016/j.jtha.2024.05.026

In resource-limited settings in which the use of standard-dose prophylaxis for severe hemophilia A without inhibitors is not possible, the ISTH Hemophilia Guideline Panel suggests prophylaxis with low-dose FVIII concentrates over episodic treatment of bleeding events (conditional recommendation, based on very low–certainty evidence ⨁◯◯◯).

In contrast, low-dose prophylaxis with FVIII was defined as 10 IU/kg, 2 times per week, according to the studies included in recommendation 4, both of which used plasma-derived FVIII.