علاج متلازمة HUS في متلازمة انحلال الدم اليوريمي المرتبطة بسموم شيغا مع الإسهال الدموي

References

DOI: 10.1007/s00467-019-04233-7

Shiga toxin-associated gut infection is one of the chief causes of HUS and confirmed by stool examination.

We recommend maintaining hydration by early use of isotonic fluids in patients with dysentery, starting from onset of bloody diarrhea to the day of onset of HUS, and monitoring for fluid overload in patients with renal failure.

We recommend therapy with appropriate antibiotics for bloody diarrhea.

Ringer lactate or dextrose saline should be infused during bloody diarrhea and including the day of diagnosis of HUS to prevent dehydration.

Since administration of intravenous fluids is not always feasible, the use of oral rehydration solution to maintain euvolemia is an alternative, but which has not been examined.

Since clinical distinction between shigellosis and STEC infection may be difficult, we recommend that patients with bloody diarrhea receive treatment with oral ciprofloxacin, azithromycin or cefixime for 5 days.