علاج ابيضاض الدم الكلاسيكي ذي الخلايا الشعيرية الذي يستوجب العلاج عندما لا يمكن السيطرة على العدوى النشطة

References

DOI: 10.1182/blood-2016-01-689422

• One of the most challenging clinical situations involves the patient with HCL who requires treatment but has an active infection.
• If it is not possible to control the infection and antileukemia therapy is needed, then a decision regarding primary therapy requires the use of either a purine analog or interferon alpha.
• Attempts to control the infection should be pursued before beginning treatment with the purine nucleoside analog.
• If active infection is present, attempts to control infection should be pursued before instituting the purine nucleoside regimen.
• If it is not possible to control infection, alternative therapy with interferon alpha, low-dose pentostatin, or newer agents (eg, vemurafenib) not associated with worsening myelosuppression may be used to improve the absolute neutrophil count in an attempt to control infection before using regular-dose purine analogs to secure a durable response.