علاج الالتهاب الرئوي بالمستدمية النزلية لدى البالغين في العيادات الخارجية مع الأمراض المزمنة المصاحبة

References

DOI: 10.1164/rccm.201908-1581ST

• For outpatient adults with comorbidities such as chronic heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancy; or asplenia we recommend (in no particular order of preference) (Table 3):
• Combination therapy: a beta-lactam AND a macrolide (strong recommendation, moderate quality of evidence for combination therapy), or doxycycline (conditional recommendation, low quality of evidence for combination therapy); OR a respiratory fluoroquinolone (strong recommendation, moderate quality of evidence).
• We recommend that the duration of antibiotic therapy should be guided by a validated measure of clinical stability (resolution of vital sign abnormalities [heart rate, respiratory rate, blood pressure, oxygen saturation, and temperature], ability to eat, and normal mentation), and antibiotic therapy should be continued until the patient achieves stability and for no less than a total of 5 days (strong recommendation, moderate quality of evidence).
• As most patients will achieve clinical stability within the first 48 to 72 hours, a total duration of therapy of 5 days will be appropriate for most patients.