علاج قصور هرمون النمو المستمر في فترة الانتقال

References

• We recommend that patients with multiple (≥3) pituitary hormone deficiencies regardless of etiology, or GHD with a documented causal genetic mutation or specific pituitary/hypothalamic structural defect except ectopic posterior pituitary, be diagnosed with persistent GHD.
• The transition period is the time from late puberty to establishment of adult muscle and bone composition, and encompasses attainment of AH.
• We suggest that GH treatment be offered to individuals with persistent GHD in the transition period.
• Three RCTs in young adults with persistent GHD indicated that 2 years of GH treatment increased bone mineral density, normalized IGF-I levels, and improved lipid profiles from baseline.