علاج مرض غريفز عندما لا يحقق الميثيمازول وضع الغدة الطبيعي

References

• The goal of RAI treatment in GD is to administer sufficient activity to render the patient hypothyroid.
• This can be accomplished with the use of a fixed dose or calculating the activity based on goiter size and RAI uptake.
• In order to achieve hypothyroidism, activity of greater than 150 μCi/g (5.55 MBq/g) should be administered.
• RAI is a β radiation emitter with a long physical half-life of just over 8 days which is rapidly concentrated by the thyroid after oral ingestion.
• Patients with active mild TED are candidates for oral glucocorticoid therapy (0.3–0.5 mg of prednisone per kg of body mass per day, started 1–3 days after RAI administration, tapered over three months).
• The β particle has a range in tissue of approximately 2 mm and induces DNA damage and eventual thyroid cell death, rendering most patients with GD hypothyroid over a period of six weeks to six months.

DOI: 10.1016/j.ecl.2021.12.004.