علاج النقرس الحاد في المرضى الذين يتناولون مثبطات P-glycoprotein و/أو CYP3A4 القوية (Cyclosporin، Clarithromycin، Ketoconazole، Verapamil)

References

1. Colchicine should not be given to patients receiving strong P-glycoprotein and/or CYP3A4 inhibitors such as cyclosporin or clarithromycin.
2. Co-prescription of colchicine with strong P-glycoprotein and/or CYP3A4 inhibitors should be avoided.
3. A pharmacokinetic study showed that strong P-glycoprotein and/or CYP3A4 inhibitors such as cyclosporin, clarithromycin, verapamil and ketoconazole when prescribed with colchicine increased colchicine plasma concentration, thereby exposing patients to risk of serious side effects.
4. A double-blind, randomised equivalence trial of crystal-proven gout from a primary care source population found that prednisolone (35 mg/day for 5 days) was equivalent to naproxen (500 mg twice a day for 5 days) for treating flare.
5. Acute flares of gout should be treated as early as possible.