الورم الأرومي الدبقي المشخص حديثاً في المرضى فوق سن 70 مع حالة وظيفية جيدة وميثيلة محفز MGMT

References

DOI: 10.1093/neuonc/noaf177

• Treatment decisions for glioblastoma after maximal safe resection depend on age, functional status, MGMT status, and patient care goals (Figure 8).
• Given the modest benefits of standard treatments, participation in clinical trials is highly recommended for patients with good performance status of any age.
• Treatment is similar to the approach for younger patients and includes maximal safe surgical resection, radiotherapy and temozolomide, although randomized studies failed to show a survival difference between biopsied and resected patients.
• Nevertheless, the goal for glioblastoma surgery should be maximal safe resection of the enhancing and non-enhancing solid tumor whenever feasible.
• Whenever microsurgical resection is deemed to be too risky based on the patient's medical condition and/or the functional topography of the affected brain region, a stereotactic or open biopsy should be performed to obtain a histological and molecular diagnosis.
• For patients in whom conventional, open surgical approaches are not deemed optimal because of surgical risk, MRI-guided laser interstitial thermal therapy, a minimally invasive technique designed to ablate tumors, is sometimes an option.