علاج ورم الخلايا العملاقة في العظام في الحوض أو العجز

References

DOI: 10.3390/curroncol31040157

• Curettage or EBR are therapeutic options in this setting.
• To preserve sacral nerve function (particularly S1, S2, and S3), tumors in the cephalic (above the S3 level) and caudal (below the S3 level) portions are commonly managed with curettage (nerve-sparing surgery) and complete resection, respectively.
• EBR is indicated for lesions with extensive cortical destruction and large soft tissue masses to achieve a safe margin.
• Li et al. evaluated seven patients with pelvic GCTB who underwent EBR and reconstruction with a 3D-printed prosthesis.
• Preoperative treatment with denosumab decreased blood loss during curettage and shortened the operative time.
• It is not recommended to administer denosumab for >3 months prior to surgery for reducing intraoperative blood loss and facilitating surgery.