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References

DOI: 10.2471/B09539.

• In the presence of any of these scenarios, empiric combination therapy with two antibiotics is recommended.
• The first agent should be selected from ciprofloxacin, ampicillin, or penicillin G, based on local penicillin susceptibility patterns (Table 4).
• The second agent should be chosen according to the clinical presentation: intravenous clindamycin for inhalation or injection-related anthrax, oral clindamycin for severe cutaneous anthrax, or intravenous gentamicin for gastrointestinal anthrax.
• Overall, treatment duration should be extended for at least 14 days or until the patient is clinically stable, whichever is longer.
• Clear clinical improvement should always be documented prior to therapy discontinuation.