ينطبق هذا البروتوكول على المرضى المصابين باللمفوما الجريبية (FL) الذين أصيبوا بانتكاسة ويحتاجون الآن إلى إعادة العلاج — في الحالات التي يُستبعد فيها التحوّل عالي الدرجة، وحيث لا تكون المرض مقاومًا للريتوكسيماب.
Offer immunochemotherapy to people with relapsed FL in need of treatment.
For those who have achieved a relatively long remission duration, consider repeat therapy with rituximab in combination with the same chemotherapy as administered previously. For those with a shorter remission duration consider rituximab in combination with an alternative chemotherapy regimen from that administered previously.
Consider up to 2 years of rituximab (or obinutuzumab if this agent was used for induction) maintenance for those people who have relapsed disease who have responded to re-induction therapy, have not received antibody maintenance previously and are not suitable for high-dose therapy.
Consider HDT-ASCR for fitter people with relapsed FL who achieve a second or subsequent remission.
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