التغيرات الليفية الكيسية في الثدي عندما لا يتحكم زيت الربيع المسائي في ألم الثدي أو تعقده

References

Treatment with tamoxifen or danazol should be reserved for severe or refractory cases due to their serious side-effects.

Tamoxifen has shown good efficacy in cyclical mastalgia (in 90% cases) in controlled trials with fewer side effects with 10 mg daily dosage.

However, recommendations for danazol administration permit 100 mg twice daily for 2 months which may be increased to 200mg twice daily in case of no response with 100mg but should be discontinued if it still does not respond.

Only in severe or refractory cases, treatment with tamoxifen or danazol may be tried but with proper caution and a beforehand explanation to patient about the possible side-effects.

Studies have reported beneficial effects in alleviating FBD symptoms with dosage of 200 and 400 mg/day; response being early with higher dosage but with more side effects and relapse being quicker with lower dosage.