علاج فقر الدم فانكوني مع متلازمة خلل التنسج النقوي في المرحلة المبكرة (دون زيادة في الأرومات)

References

DOI: 10.1182/hematology.2023000489

• For patients with early-stage MDS without excess blasts such as the one in our case, most centers recommend proceeding directly to HSCT with best available donor.
• Subsequently, improved outcomes have been made possible by T-cell depletion strategies such as CD34 selection and TCRαβ depletion to limit graft-versus host disease (GvHD) and by use of low-intensity regimens to reduce organ toxicity.
• Posttransplant cyclophosphamide has also proven to be an effective method of in vivo T-cell depletion for patients with FA undergoing HSCT with haploidentical donors.