علاج الورم الغدي القابل للاستئصال المتقدم موضعياً للمريء والوصل المريئي المعدي

References

• Based on the results of CROSS, preoperative CRT can be recommended as one standard of care for locally advanced AC of the oesophagus and OGJ.
• Patients with resectable, locally advanced oesophageal AC or OGJ cancer should be treated with neoadjuvant CRT based on the CROSS regimen or perioperative ChT (FLOT) followed by surgery [I, A; ESMO-MCBS v1.1 score: A].
• Weekly carboplatin–paclitaxel combined with radiation to a dose of 41.4 Gy in 23 fractions followed by oesophagectomy showed improved survival compared with surgery alone for both SCC and AC.
• The phase II/III FLOT4-AIO trial compared perioperative ECF with four preoperative and four post-operative cycles of 5-FU–leucovorin–oxaliplatin–docetaxel (FLOT), and showed an OS benefit for FLOT.