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References

• Treatment approach should include discontinuation of any unnecessary medications and appropriate workup to exclude an underlying malignancy.
• Regulating environmental temperature is crucial since patients with this condition loose homeostatic body functions that prevent cooling or overheating.
• Skin barrier function can be improved with colloid baths and wet compresses on not more than a quarter of the body at a time, along with emollient creams and low-potency topical corticosteroids.
• Oral, intramuscular or intravenous sedative antihistamines can alleviate scratching, thus preventing secondary skin infections while relieving pruritus and anxiety (eg, hydroxyzine hydrochloride, 25-50 mg P.O. QID).
• Individualize antimicrobial treatment if evident clinical signs of secondary bacterial infection (i.e. bleach baths and intranasal mupirocin in severe AD; cephalexin 250-500 mg QID in extensive impetigo lesions).