علاج الحمامى متعددة الأشكال المتكررة — المرتبطة بفيروس الهربس البسيط أو مجهولة السبب

References

DOI: 10.3390/medicina57090921

• In both HSV-associated EM and idiopathic EM, the first-line treatment is antiviral prophylaxis.
• Additionally, other systemic agents may be used.
• If resistant to prophylactic antivirals, systemic agents that may be used include: azathioprine, dapsone, mycophenolate mofetil, or immunoglobulin hydroxychloroquine, thalidomide, and cyclosporine.
• Antibiotics, azithromycin, and dapsone specifically, have both produced clinical improvement in patients with recurrent EM.
• An observational study from 2018 demonstrated that levamisole showed significant reduction in EM recurrence in 23 patients, compared to standard therapy with corticosteroids and antiviral therapy.
• Additionally, a single patient with recurrent EM had a rapid and complete response to treatment with adalimumab.
• Another case series from 2017 described the use of apremilast in 3 patients with recurrent oral EM.