علاج سرطان بطانة الرحم منخفض الخطورة: المرحلة الجزيئية من IAm إلى IIm (POLEmut، MMRd، NSMP)

References

DOI: 10.1016/S1470-2045(25)00167-6

• Low risk includes four categories (figures 3, 4; green cells).
• First, stages IA molecular (m; IA1, IA2, or IA3) POLEmut, MMRd, or NSMP low-grade and oestrogen receptor-positive endometrial carcinoma.
• Second, stage IBm POLEmut endometrial carcinoma.
• Third, stage ICm POLEmut or MMRd endometrial carcinoma.
• Fourth, stages IIm (IIA, IIB, or IIC) POLEmut endometrial carcinoma.
• Standard surgery for stage I and II endometrial carcinoma is total hysterectomy with bilateral salpingo-oophorectomy and lymph node staging (II, A for stage I and IV, B for stage II).
• Minimally invasive surgery is the preferred surgical approach, including for patients with high-risk endometrial carcinoma (I, A).
• Sentinel lymph node biopsy should be done for staging purposes in all patients with presumed uterus-confined disease (II, A).
• For patients with low-risk endometrial carcinoma, no adjuvant therapy is recommended (II, A; figure 5).