علاج سرطان بطانة الرحم عالي الخطورة: المراحل من IA2m إلى IVAm

References

DOI: 10.1016/S1470-2045(25)00167-6

• High-risk includes four categories (figures 3, 4; red cells).
• First, stages IA2m, IA3m, or IBm NSMP high-grade or oestrogen receptor-negative (or both), or stages IA2m, IA3m, or IBm p53abn endometrial carcinomas.
• Second, stages IIm (IIA, IIB, or IIC) NSMP high-grade or oestrogen receptor-negative (or both), or p53abn endometrial carcinoma.
• Third, stages IIIm (IIIA, IIIB, or IIIC) MMRd, NSMP low-grade and oestrogen receptor-positive, NSMP high-grade or oestrogen receptor-negative (or both), or p53abn endometrial carcinomas.
• Fourth, stages IVAm MMRd, NSMP low-grade and oestrogen receptor-positive, NSMP high-grade or oestrogen receptor-negative (or both), or p53abn endometrial carcinomas.
• For patients with high-risk endometrial carcinoma, external beam radiotherapy with concurrent and adjuvant chemotherapy (I, A) or, alternatively, sequential chemotherapy and radiotherapy, are recommended (I, B).
• Chemotherapy with or without brachytherapy is an alternative option (I, B).