علاج سرطان بطانة الرحم المصنف ضمن الخطر المتوسط إلى العالي

References

DOI: 10.1016/S1470-2045(25)00167-6

1. High–intermediate risk includes three categories (figures 3, 4; orange cells).
2. First, stage IIAm MMRd endometrial carcinoma.
3. Second, stage IIBm MMRd, or NSMP low-grade and oestrogen receptor-positive endometrial carcinoma.
4. Third, stage IICm MMRd endometrial carcinoma with cervical invasion (independent of lymphovascular space invasion) or with substantial lymphovascular space invasion.
5. For patients with high–intermediate-risk endometrial carcinoma, adjuvant external beam radiotherapy is recommended for optimal pelvic control (II, A).
6. Vaginal brachytherapy is an alternative option, especially for patients who underwent lymph node staging and are pN0 (II, B).
7. No adjuvant therapy can be considered, especially for patients who underwent lymph node staging and are pN0 without substantial lymphovascular space invasion and low-grade disease (IV, B; figure 5).