علاج سرطان بطانة الرحم المصنّف ضمن الخطورة العالية المتوسطة

References

DOI: 10.1016/S1470-2045(25)00167-6

• High–intermediate risk includes three categories (figures 3, 4; orange cells).
• First, stage IIA^m MMRd endometrial carcinoma.
• Second, stage IIB^m MMRd, or NSMP low-grade and oestrogen receptor-positive endometrial carcinoma.
• Third, stage IIC^m MMRd endometrial carcinoma with cervical invasion (independent of lymphovascular space invasion) or with substantial lymphovascular space invasion.
• Standard surgery for stage I and II endometrial carcinoma is total hysterectomy with bilateral salpingo-oophorectomy and lymph node staging (II, A for stage I and IV, B for stage II).
• Sentinel lymph node biopsy should be done for staging purposes in all patients with presumed uterus-confined disease (II, A).