الداء النوكاردي المنتشر مع خراج دماغي: عندما لم يحقق العلاج التوافقي الأولي للجهاز العصبي المركزي الحل الإشعاعي

References

DOI: 10.1093/cid/ciae643

• The most common site of dissemination is the central nervous system (CNS), typically manifesting as cerebral abscesses.
• Patients with TMP-SMX toxicity and yet-to-improve severe infection may be better served transitioning to alternative therapy, as patients with severe nocardiosis are underrepresented in the available data.
• Linezolid is uniquely susceptible in vitro to essentially all Nocardia isolates.
• Reduction in immunosuppression is often performed for severe disease, though evidence supporting this is limited.
• Immunosuppression should be lowered or held if it can be done safely, recognizing the competing risks of rejection and graft-versus-host disease in transplant populations.