علاج داء النوكارديا المنتشر مع انتشار إلى الجهاز العصبي المركزي وخراج دماغي

References

DOI: 10.1093/cid/ciae643

• The most common site of dissemination is the central nervous system (CNS), typically manifesting as cerebral abscesses.
• This is particularly crucial in severe forms of nocardiosis (eg, disseminated or progressive pulmonary infection), where 2 or 3 different agents are typically initiated empirically.
• In CNS nocardiosis specifically, about half of patients undergo abscess debridement or stereotactic needle aspiration.
• Patients with localized pulmonary nocardiosis are traditionally treated for up to 6 months, while those with disseminated disease (particularly involving the CNS) are commonly treated for at least 12 months.
• Patients with CNS involvement are commonly treated until radiographic resolution, though CNS lesions may not fully resolve and evidence supporting this practice is lacking.