علاج داء المخمورات المنتشر مع إصابة الجهاز العصبي المركزي (الدماغ)

References

1. In CNS involvement, animal models and the above observations support use of liposomal amphotericin B at 10 mg/kg per day.
2. The guideline group strongly supports an early complete surgical treatment for mucormycosis whenever possible, in addition to systemic antifungal treatment.
3. Doses should not be slowly increased over several days; rather, the full daily dose should be given from the first treatment day.
4. When switching to oral treatment, use of isavuconazole or posaconazole delayed release tablets is strongly supported.
5. In view of the rapid progress of mucormycosis, weekly CT scans are strongly recommended, particularly in unstable patients.
6. Therapy can be continued until resolution of signs and symptoms of infection, and substantial radiographical improvement.