داء المخاطيات المنتشر: عندما لا يحقق العلاج المضاد للفطريات من الخط الأول السيطرة على المرض

References

• Isavuconazole is strongly supported as salvage treatment.
• Posaconazole delayed release tablets or infusions are strongly supported for salvage treatment, and when available should be preferred over posaconazole oral suspension, which in turn is marginally supported for salvage treatment.
• In cases of primary treatment failure with isavuconazole or posaconazole, the guideline group supports recommendations for all three lipid-based amphotericin B formulations with strong to moderate strength.
• In case of extensive disease, rapid progression, or poor general condition, the addition of isavuconazole or posaconazole can be considered.
• Limited data support combinations of polyenes and azoles or polyenes plus echinocandins.
• Therapy can be continued until resolution of signs and symptoms of infection, and substantial radiographical improvement.