استبدال خلايا بيتا عن طريق الزراعة في داء السكري من النوع الأول

References

DOI: 10.2337/dci21-0043

• Whole organ pancreas and pancreatic islet transplantation are currently the only means of clinical b-cell replacement (Fig. 7).
• Islet transplantation, a less invasive procedure, is indicated in people with excessive glycemic lability and frequent level 3 hypoglycemia despite optimal medical therapy, and allows for inclusion of older people and those with coronary artery disease who would not be eligible for a whole-pancreas transplant.
• Most whole-pancreas transplants are performed simultaneously with a kidney transplant (simultaneous pancreas and kidney [SPK] transplant).
• Regardless of the b-cell replacement approach (pancreas or islets), the majority of recipients experience reliable prevention of problematic hypoglycemia with near-normal glycemic levels.