الخرف بأجسام ليوي مع الهلوسات البصرية والأوهام واللامبالاة: عندما لا تحقق مثبطات الكولينستيراز سيطرة كافية

CHEIs may produce substantial reduction in apathy and improve visual hallucinations and delusions in DLB.

The use of antipsychotics for the acute management of substantial behavioral disturbance, delusions, or visual hallucinations comes with attendant mortality risks in patients with dementia, and particularly in the case of DLB they should be avoided whenever possible, given the increased risk of a serious sensitivity reaction.

Low-dose quetiapine may be relatively safer than other antipsychotics and is widely used, but a small placebo-controlled clinical trial in DLB was negative.

There is a positive evidence base for clozapine in PD psychosis, but efficacy and tolerability in DLB have not been established.

Newer drugs targeting the serotonergic system, such as pimavanserin, may be alternatives, but controlled clinical trial data in DLB are needed.