مرض دارييه مع آفات جلدية معممة عندما لم يسيطر العلاج الداعم على الحكة

References

• Oral retinoids were the most effective oral therapy and were prescribed in the cases of generalized Darier disease.
• Burge et al. were the first to use oral etretinate in 1981, at a dose of 0.5–1.0 mg/kg in 18 patients with Darier disease, 17 of which improved.
• Efficacy of acitretin in Darier disease was assessed in 1 case series where 4 out of the 5 patients improved, using starting doses of 35 mg daily for the first 3 months then adjusting the dose according to the response.
• In another article, acitretin was used to treat 13 patients with a dose starting at 30 mg per day for 16 weeks.
• The starting dose that was used was 0.5 mg/kg and the maintenance dose was adjusted according to symptoms.
• It was found to be very effective with 73 (70%) patients showing clinical improvement after 1 to 4 weeks according to both patients and the physicians.