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References

DOI: 10.1093/cid/ciae643

In contrast, patients with severe nocardiosis are typically hospitalized and have a more rapid course from onset to diagnosis.

This is particularly crucial in severe forms of nocardiosis (eg, disseminated or progressive pulmonary infection), where 2 or 3 different agents are typically initiated empirically.

Patients with TMP-SMX toxicity and yet-to-improve severe infection may be better served transitioning to alternative therapy, as patients with severe nocardiosis are underrepresented in the available data.

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