الليشمانيا الجلدية البسيطة سريريًا عندما لا يحقق العلاج الجهازي المضاد للليشمانيا أهداف الاستجابة العلاجية

References

• We recommend that immunocompetent persons with skin lesions that are caused by infection with Leishmania species that are not associated with increased risk for ML, that are defined as clinically simple lesions (Table 1), and that are healing spontaneously may be observed without treatment if the patient concurs with this management.
• Local therapy is preferred for treatment of Old World cutaneous leishmaniasis (OWCL) lesions defined as clinically simple (Table 1) and may be useful for localized NWCL caused by Leishmania species not associated with increased risk for ML.
• Additional therapy is recommended (but not necessarily always with a different agent or approach) when there is development of new skin lesions or worsening of existing lesions.
• For some patients, combination therapy may be an option — for example, with 2 antiparasitic agents, an antiparasitic plus a physical modality (such as with IL SbV plus cryotherapy), or an antiparasitic plus an immune modulator.