ما هو علاج الخط الأول للأميبيات الجلدية؟

DOI: 10.1093/ofid/ofy161

• Patients with clinical disease require treatment with 2 drugs: an amebicidal tissue-active agent and a luminal cysticidal agent.
• The amebicidal agents include metronidazole and tinidazole, which are both nitroimidazole agents.
• They are highly effective at eliminating invading trophozoites and remain the recommended therapy for amebic colitis and amebic liver disease.
• The nitroimidazoles do not effectively eradicate luminal cysts and must be followed by a luminal agent.
• The aminoglycoside paromomycin is a luminal cysticidal agent.
• As it may cause diarrhea, paromomycin should not be administered at the same time as the nitroimidazole agent.